ABSTRACT
The paper presented the characteristics of ambulatory surgery and the construction of a standardized management system in pediatrics. Every step of the process is standardized. Admission criteria cover all, including the children patients, surgeons, anesthesiologists, and surgical procedures, while preoperative postoperative evaluation is made and upon discharge as well. Surgery cancellation rate is reduced at all dimensions. Such rapid rehabilitation measures as preventive anti-vomiting, and shorter perioperative fasting time were introduced, along with effective post-discharge support. These efforts aim at exploring the safety and efficacy of standardized management approaches for pediatric day surgery, providing references for specialized pediatric hospitals.
ABSTRACT
Astrocytes are closely associated with Alzheimer's disease (AD). However, their precise roles in AD pathogenesis remain controversial. One of the reasons behind the different results reported by different groups might be that astrocytes were targeted at different stages of disease progression. In this study, by crossing hAPP (human amyloid precursor protein)-J20 mice with a line of GFAP-TK mice, we found that astrocytes were activated specifically at an early stage of AD before the occurrence of amyloid plaques, while microglia were not affected by this crossing. Activation of astrocytes at the age of 3-5 months did not affect the proteolytic processing of hAPP and amyloid plaque loads in the brains of hAPP-J20 mice. Our data suggest that early activation of astrocytes does not affect the deposition of amyloid β in an animal model of AD.